Hypercoagulation & Boluoke

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Hypercoagulation is a thickened blood state, and means that your body is producing fibrin strands faster than it can break them down. When this happens, the fibrin may get deposited on the capillary walls. This impedes the delivery of oxygen and nutrients from the blood to the tissues, while also preventing the expulsion of waste chemicals from the tissues to the blood. If this situation persists for a prolonged period of time, the tissues in the body gradually become hypoxic (lacking in oxygen) and malnourished. The end result is often an acidic tissue environment, pain, lack of energy, and the decline of organ functions. Hypercoagulation also pre-disposes a person to clot formation in blood vessels, especially if atherosclerosis is already present.

Modern research has clearly shown that hypercoagulation is often present in patients with chronic illnesses. If the hypercoagulation condition is not addressed in these patients, they often do not improve or relapse easily. The cause of hypercoagulation must also be addressed in order to achieve a cure or lasting improvement. Some of the most common causes of hypercoagulation are infections, coagulation protein defects (these are inherited), and heavy metal or chemical toxicities.

What is Boluoke?

Boluoke (lumbrokinase) is a revolutionary product with a special ability to balance the body's clotting system and maintain a healthy circulation. The main ingredient found in Boluoke is a group of earthworm enzymes collectively called lumbrokinase. For many centuries the earthworm has been used in Far East traditional medical practice. Korean and Chinese researchers have compiled extensive scientific and clinical data on lumbrokinase. In Korea, lumbrokinase has been used to coat artifical heart valves, and has been shown to be effective in reducing the fibrins sticking to the heart valves. Chinese researchers have put Boluoke through various trials and have used it clinically for hypercoagulation and clot-induced hypoperfusion (diminished blood flow) conditions since the early 1990s with excellent results.

Boluoke Facts

Scientific name: A proprietary enzyme mixture containing lumbrokinase extracted from earthworms (Eisenia Fetida)

Main Function

  • Supports and maintains healthy coagulation activity of the body

Physiological effects already shown in scientific literature

  • Activates plasminogen system and hydrolyzes fibrin directly
  • Lowers PAI-1, fibrinogen, ESR, and C-RP levels
  • Lowers whole blood viscosity & plasma viscosity
  • Reduces platelet aggregation

Potential applications

Many acute and chronic conditions commonly associated with modern diet and lifestyle often lead to a hypercoagulable blood state, which means the body’s fibrinolytic activity is under-functioning relative to the body’s pro-coagulation activity. In a hypercoagulable state, these two systems are out of balance and the blood is more prone to forming excessive fibrin. Boluoke can support the body’s fibrinolytic system and bring the whole system back into a more balanced state. Hypercoagulation is not a disease, but merely a blood state that is often associated with many conditions. However, it can contribute to the progression of many conditions if it is not brought back into balance. The causes of hypercoagulation may be inflammation, infection, trauma, toxicities, etc., and correcting the underlying causes is the long-term solution.

Major advantages

  • Oral preparation; no injection required
  • Supported by scientific and human data
  • Does not significantly affect INR, PT, or aPTT
  • Standardized enzymatic strength
  • Excellent safety records and well tolerated


  • Maximal effect: 2 capsules 3x per day 30 minutes before each meal for 3-6 weeks or as recommended by a physician
  • Maintenance: 1 capsule 1-3x per day 30 minutes before each meal


  • Recent surgery, lumbar/arterial puncture, or trauma
  • Known aneurysm, GI ulceration/bleeding, or any bleeding disorders
  • Concurrent administration of strong anti-platelets like Plavix, Ticlid, etc.
  • Known allergy to lumbrokinase, earthworms, or corn

Conditions Often Associated with Hypercoagulation:

  • Cancer
  • Ischemic Stroke History
  • Fibromyalgia
  • Crohn's Disease
  • Taking Birth Control Pills
  • Chronic Infections
  • Hip Fracture
  • Elevated Homocysteine
  • Lyme Disease
  • Elevated Serum CRP
  • Heart Attack History
  • Chronic Fatigue Syndrom (CFS)
  • Transient Ischemic Attacks
  • Elevated Plasma Fibrinogen
  • Hormone Replacement Therapy
  • Deep Venous Thrombosis (DVT)
  • Being on Long Flights
  • Habitual Miscarriages
  • Eleveated Serum Lp(a)
  • Gulf War Syndrome
  • Excessive Heavy Metal Burden
  • Diabetes
  • Angina
  • Ulcerative Colitis
  • Thrombocythemia
  • Polycythemia
  • Lupus
  • Vascular Dementia
  • Infertility
  • Multiple Sclerosis
  • Autism
  • Meniere's Disease